Hypoadrenocorticism (Addison's disease) is a syndrome resulting from glucocorticoid and mineralocorticoid deficiency. In most cases of hypoadrenocorticism the abnormality is located in the adrenal cortex (primary adrenal failure), resulting in deficiency of usually both cortisol and aldosterone from the adrenal cortex. More rarely, Addison's disease may be due to dysfunction of the hypothalamic-pituitary axis resulting in a failure of ACTH secretion and pure glucocorticoid deficiency (secondary adrenal failure). In secondary hypoadrenocorticism, mineralocorticoid secretion is normal.
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