Systemic inflammatory response syndrome

摘要

Systemic Inflammatory Response Syndrome (SIRS) is a clinical syndrome often associated with sepsis, severe trauma, severe pancreatitis, heat stroke, and any condition associated with prolonged hypo-perfusion or tissue hypoxia (cardiovascular shock,post-cardiopulmonary arrest). Common clinical findings in SIRS include tachycardia, (often bradycardia in cats), tachypnea, fever or hypothermia, leukocytosis or leukopenia, and hypotension among others. The clinical scenario of SIRS is extremely variable and depends on several factors including the extent of tissue trauma/infection, the time course, and individual differences in response to injury/infection among patients. Because of this, it is difficult to define unifying characteristics of SIRS, other than to understand which patients are at risk for SIRS and identifying those that have components of systemic inflammation. Clinical and laboratory characteristics of SIRS include mental depression to stupor/coma, interstitial edema, hypotension, myocardial dysfunction, Acute Respiratory Distress Syndrome, acute renal insufficiency, hepatic dysfunction, sepsis (secondary), hypoalbuminemia, hyper- or hypoglycemia, hvperbilirubinemia, hypoxemia, hyperor hypocarbia, lactic acidosis, hyper- or hypocoaguability, and thrombocytopenia.