Thiazole, which is a five-metnbered heteroaromatic compound composed of nitrogen and sulfur atom, shows remarkable properties as functional organic materials as well as biologically important molecules. Synthesis of substituted thiazole derivatives is thereby a major concern in synthetic organic chemistry. The cross-coupling methodology with a transition metal catalyst is a practical tool for the introduction of a substituent into the thiazole ring. In particular, direct coupling of a thiazole derivative at the carbon-hydrogen bond by the catalysis of palladium is one of the practical way to introduce aryl and alkenyl groups via the carbon-carbon bond formation.
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