Halogenotin Hydride Catalyzed Reductive Aldol Reaction of Enones with Ketones

摘要

The reductive aldol reaction of enones with aldehydes promoted by metal hydrides is a valuable method for obtaining β-hydroxyketones in one-pot synthesis. We have already reported that using iododibutyltin hydride (Bu2SnIH) as stoichiometric metal hydride promoted reductive aldol reaction of enones with aldehydes. However, the reaction of enones with ketones instead of aldehydes have not been reported due to less reactivity of ketones as electrophiles. We investigated catalytic use of halogenodibutytin hydride, and found the high diastereo-selective reactions of enones with ketones (Scheme 1).