A Synthetic Approach to Aromatic Compounds Using Ring-Closing Olefin Metathesis

摘要

Ruthenium-catalyzed ring-closing olefin metathesis (RCM) has emerged as a valuable tool for the preparation of substituted aromatic compounds in recent years.We have also been interested in the development of synthetic methods for carbocyclic aromatic compounds using RCM.In our first report,we showed that phenol derivatives 2,which are one of the most important classes of aromatic compounds,can be prepared from l,4,7-trien-3-ones 1 using the RCM/tautomerization protocol in which the ketonic tautomers of the phenols are advantageously generated (eq l).