The non-lactating (dry) period is well known as an important time for both the acquisition and treatment of intramammary infections. Although systemic use of antibiotic has been used in conjunction with intramammary therapy in lactating cattle, intramammary therapy alone has been routinely used for dry cow therapy (1). Previous research (2,3) has suggested that systemic therapy may be beneficial but most producers rely solely on intramammary dry cow therapy (DCT). It has been suggested that systemicantibiotics possess pharmacokinetics that enable better penetration into the udder tissue and improves the success of DCT. This study was designed to compare the use of an intramammary antibiotic alone or in conjunction with either systemic tylosin (Tylan, Blanco Animal Health) or oxytetracycline ( LA 200, Pfizer, Inc).
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