A SYSTEMATIC MODEL REDUCTION PROCEDURE FOR COMPLEX BIOPROCESSES DESCRIBED BY METABOLIC PATHWAY NETWORKS

摘要

In this study, a class of dynamic models based on metabolic reaction pathways is analysed, showing that systems with complex intracellular reaction networks can be represented by macroscopic reactions relating extracellular components only. Based on rigorous assumptions, the model reduction procedure is systematic and allows an equivalent 'input-output' representation of the system to be derived. The procedure is illustrated with a few examples.