SIZE DEPENDENT MOBILITY OF DNA IN ELECTRIC AND HYDRO DRAG FORCE FIELD

摘要

The migration velocities of DNA were measured in microfabricated taper-shape channels where both the hydro pressure and the electric force were applied at the same time in mutually reverse directions. If the both force were larger than a threshold, DNA was trapped near the narrowest position of the channel. In this case, the trap probability appeared to depend on DNA size; larger DNA has larger probability. On the other hand, when the both force were lower than the threshold, DNA migrated in the channel. In some conditions of this case, the migration velocity showed strong dependence on DNA size.