REDUCTION OF MICROFLUIDIC END EFFECTS IN MICRO-FIELD FLOW FRACTIONATION CHANNELS

摘要

This work introduces a novel approach for the reduction of fluidic end effects, which give rise to the particle band broadening and zone dispersion, a critical performance parameter for micro- field flow fractionation (FFF) and other separation systems. The approach includes the implementation of pillars in the microchannel to help ensure that all particle paths are identical in length. Modeling results show significant reductions in plate heights and these results are confirmed experimentally.