Naturally fluid and functional biological membranes have been integrated into a scaleable system. Previously-inaccessible membrane targets can be presented in their native environment. Domains of membrane targets naturally displayed in cell membranes can be exposed for drug discovery. The MembraneChip~(TM) is an array of 16-64 distinct membrane targets in their fluid lipid bilayer environment. Each lipid bilayer expanse is corralled on a micron scale. MembraneChips~(TM) have been made compatible with standard well plate systems. Its architecture achieves natural cell membrane properties in a scalable and controllable configuration for novel drug discovery.
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