petection of High Risk Oncogenic Human papillomavirus in Women Patient with CIN 3 Lesions

摘要

A cohort of 4364 women with atypical cytology were referred to colposcopic examination. Punch biopsy performed for colposcopically suspicious lesions. In the study group, 842 (19,3%) cytology were suggestive for HG-SIL and colposcopy found a number of 916(20,9%) images with major changes, suggestive for HG-SIL.The histopathologi-cal examination revealed CIN 1-224 (20,21%) cases, CIN 2-758(68,41%) cases and CIN 3-126(11,37%) cases. For all cases with CIN 3 lesions it had been performed the HC II Assay, to detect the presence of HR HPV oncogenic genotypes, which had been detected for 119(94,4%) cases. After surgical treatment of CIN 3 lesions, the HPV testing was used to discriminate patients who will have recurrences from those who will not. Post treatment, 11(8,7%) patients presented latent infection with the same HR HPV types, being at high risk of CIN recurrences and 115 (91,3%) patients remained disease free.