Inhibition of C-Reactive Protein After Implantation of a Sirolimus-Eluting Stent

摘要

Background C-reactive protein (CRP) is an important prognostic marker in patients undergoing coronary intervention. The effect of sirolimuseluting stents on CRP levels has not been studied.Methods and Results. We measured levels of high sensitivity (hs)-CRP in 97 consecutive patients receiving a sirolimus-eluting stent. Levels of lis-CRP were determined before stent implantation, the following morning and after one month. Levels of hs-CRP increased by 30% after the procedure (p<0.001) and decreased thereafter to baseline levels (p<0.001). Patients with acute myocardial infarction and unstable angina had the highest levels of pre-procedural hs-CRP and a robust reduction to baseline levels at one month.Conclusions. Sirolimus-eluting stents are associated with a significant and rapid decrease of hs-CRP after implantation.