Coronary in-stent restenosis after sirolimus-eluting stent implantation is accompanied by elevated plasma level of eosinophil cationic protein

摘要

The aim of this study was to assess the involvement of eosinophil cationic protein (ECP) and eosinophil-derived neurotoxin (EDN) in the development of in-stent restenosis after sirolimus-eluting stent (SES) implantation. Follow-up angiography at 6 to 12 months was performed in 32 patients who were treated with percutaneous coronary intervention and implantation of sirolimus-eluting stents. There were no differences between the EDN, hs-CRP and IgE levels in patients with or without restenosis. In contrast, ECP level was higher in patients with restenosis compared with that in patients without restenosis [17.7 ng/ml (11.2-24.0) vs. 9.0 ng/ml (6.4-12.9), p=0.017]. The incidence of in-stent restenosis was 62% in patients with ECP level higher than or equal to 11 ng/ml and 19% in patients with ECP level lower than 11 ng/ml (p=0.019).