ENHANCED CELLULAR UPTAKE OF ANTISENSE OLIGONUCLEOTIDES BASED ON CATIONIC LIPID OF CHOLESTEROL DERIVATIVE

机译：基于胆固醇衍生物的阳离子脂质增强反义寡核苷酸的细胞吸收

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The cationic liposomes consisted of 3β [N-(N', N'-dimethylaminoethan)-carbamoyl] cholesterol (DC-Choi) and soybean phosphatidylcholine (SPC) are designed to enhance cellular uptake of antisense oligonucleotides (ASON). The size and incorporation efficiency of liposomes are determined. Transfection conditions including cell lines, charge ratio and serum concentration are investigated.

机译：阳离子脂质体由3β[n-（n'，n'-二甲基氨基氨基氨基甲烷）-carbamoyl]胆固醇（DC-CHOI）和大豆磷脂酰胆碱（SPC）旨在增强反义寡核苷酸（ASON）的细胞吸收。确定脂质体的尺寸和掺入效率。研究了递转染条件，包括细胞系，电荷比和血清浓度。

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《Annual meeting of the Controlled Release Society》|2002年||共2页
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Chen Hai-liana; Liang Wen-quan; Li Min-wen;
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正文语种
中图分类制药化学工业;
关键词
cationic liposomes; DC-Choi; antisense oligonucleotides; transfection;

机译：阳离子脂质体;DC-CHOI;反义寡核苷酸;转染;

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专利

1. Enhanced cellular uptake of biotinylated antisense oligonucleotide or peptide mediated by avidin, a cationic protein [J] . Boado Ruben J., Pardridge William M. FEBS Letters . 1991,第1a2期

机译：阳离子蛋白抗生物素蛋白介导的生物素化反义寡核苷酸或肽的细胞摄取增强
2. Cholesterol-Appended beta-(1-> 3)-D-Glucan Schizophyllan for Antisense Oligonucleotides Delivery to Enhance the Cellular Uptake [J] . Kazuya Koumoto, Masami Mizu, Takahisa Anada, Bulletin of the Chemical Society of Japan . 2005,第10期

机译：胆固醇附加的β-（1-> 3）-D-葡聚糖Schizophyllan用于反义寡核苷酸的传递，以增强细胞摄取。
3. Cellular delivery of cationic lipid nanoparticle-based SMAD3 antisense oligonucleotides for the inhibition of collagen production in keloid fibroblasts [J] . JinS.-E., KimC.-K., KimY.-B. European journal of pharmaceutics and biopharmaceutics: official journal of Arbeitsgemeinschaft fuer Pharmazeutische Verfahrenstechnik e.V . 2012,第1期

机译：基于阳离子脂质纳米颗粒的SMAD3反义寡核苷酸的细胞递送，可抑制瘢痕loid成纤维细胞中胶原蛋白的产生
4. ENHANCED CELLULAR UPTAKE OF ANTISENSE OLIGONUCLEOTIDES BASED ON CATIONIC LIPID OF CHOLESTEROL DERIVATIVE [C] . Chen Hai-liana, Liang Wen-quan, Li Min-wen Proceedings of the 29th Annual Meeting of the Controlled Release Society . 2002

机译：基于胆固醇衍生物的阳离子脂质增强细胞对反义寡核苷酸的摄取
5. Antisense oligonucleotides directed to the HIV-1 Rev Response Element: Effects of nucleotide modification on oligo binding affinity, nuclease stability, and cellular uptake. [D] . Prater, Chrissy E. 2006

机译：针对HIV-1 Rev反应元件的反义寡核苷酸：核苷酸修饰对寡核苷酸结合亲和力，核酸酶稳定性和细胞摄取的影响。
6. Poly(propylacrylic acid) enhances cationic lipid mediated delivery of antisense oligonucleotides [O] . Li Kim Lee, Charity L. Williams, David Devore, -1

机译：聚（丙丙烯酸）增强阳离子脂质介导的反义寡核苷酸的传递
7. Enhanced cellular uptake of biotinylated antisense oligonucleotide or peptide mediated by avidin, a cationic protein [O] . Pardridge William M., Boado Ruben J. 1991

机译：阳离子蛋白抗生物素蛋白介导的生物素化反义寡核苷酸或肽的细胞摄取增强

ENHANCED CELLULAR UPTAKE OF ANTISENSE OLIGONUCLEOTIDES BASED ON CATIONIC LIPID OF CHOLESTEROL DERIVATIVE

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