Influence of realistic skull and white matter anisotropy on the inverse problem in EEG/MEG-source localization

摘要

The inverse problem in the field of EEG and MEG requires the repeated simulation of the field distribution for a given dipolar source in the human brain using a volume-conduction model of the head. High resolution finite element head modeling allows the inclusion of tissue conductivity inhomogeneities and anisotropics. We will present new approaches for individually determining the direction-dependent conductivities of skull and brain while matter, based on non-invasive multimodal magnetic resonance imaging data, and for generating a high resolution realistically shaped anisotropic finite element model of the human head. Forward calculation and inverse localization errors indicate the necessity of the chosen complex forward model.