Syntheses, Electrochemistry and Cytotoxicity of Ferrocene-containing Polyaspartamides as Water-soluble Polymeric Drug Carrier/Drug Conjugates

摘要

A general strategy towards the syntheses of water-soluble polymeric drug carriers and their drug conjugates is described. Methods of drug uptake by cells, drug release from the polymeric carrier and the relevance of electrochemistry to drug activity of the ferrocenyl group are highlighted. The advantages of these polymeric systems are demonstrated utilising cytotoxicity results of a polyaspartamide-ferrocenyl conjugate.