Advanced Luminescent Labels, Probes and Beads and their Application to Luminescence Bioassay and Imaging

摘要

The design of fluorescent probes (and labels) is as challenging as it ever was. Such probes enable studies on the molecular dimensions and dynamics of even complex (bio)matter, but also bioanalytical and screening assays whose sensitivity can reach the single molecule level. The design of advanced labels for bioassays is paralleled by developments in (laser) fluorescence spectroscopy, opto-electronics and data processing. Light-emitting diodes (LEDs) and diode lasers (DLs) are particularly attractive light sources and we therefore have focused our research (a) on labels that are LED- or DL-compatible, and (b) on applications of such labels to various analytical formats.