Surface Modification and In Vitro Blood Compatibilities of Polyurethanes Containing α-Amino Acids in the Main Chain

摘要

Polyurethanes containing γ-benzyl L-glutamate segments (PUBLG) were synthesized using 4,4'-diphenylmethane diisocyanate, poly(tetramethylene glycol), and amino-terminated γ-benzyl L-glutamate oligomer as the chain extender. Heparin-immobilized PUBLG (PUBLG-H) was prepared by hydrolysis reaction of PUBLG with an alkaline aqueous solution, followed by a coupling reaction with heparin. The activation of plasma proteins, platelets and peripheral blood mononuclear cells were significantly suppressed on PUBLG-H, suggesting good in vitro blood compatibility.