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Irradiation Design for an Experimental Murine Model

机译:实验小鼠模型的辐照设计

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In radiotherapy and stereotactic radiosurgery, small animal experimental models are frequently used, since there are still a lot of unsolved questions about the biological and biochemical effects of ionizing radiation. This work presents a method for small-animal brain radiotherapy compatible with a dedicated 6MV Linac. This rodent model is focused on the research of the inflammatory effects produced by ionizing radiation in the brain. In this work comparisons between Pencil Beam and Monte Carlo techniques, were used in order to evaluate accuracy of the calculated dose using a commercial planning system. Challenges in this murine model are discussed.
机译:在放射疗法和立体定向放射外科,频繁使用小动物实验模型,因为仍然有很多关于电离辐射的生物学和生物化学作用的未解决问题。这项工作提出了一种与专用6mV LinaC兼容的小动物脑放射疗法的方法。该啮齿动物模型专注于对大脑中电离辐射产生的炎症作用的研究。在这种工作比较铅笔梁和蒙特卡罗技术的比较中,用于使用商业规划系统评估计算的剂量的准确性。讨论了该小鼠模型中的挑战。

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