In vitro Apatite Deposition and Biodegradation of Porous Gelatin-Silicate Hybrids Derived from Sol-Gel Process

摘要

Ca(II)containing porous hybrids of gelatin and 3-(glycidoxypropyl)trimethoxysilane(GPSM)were prepared with sol-gel processing and freeze-drying techniques.The freezing temperature could control porosity and pore size of the hybrids.The biodegradation rate of the hybrids in a Tris buffer solution decreased with an increase in GPSM content.The bone-like apatite layer could form on the Ca(II)containing porous gelatin-silicate hybrids when they were soaked in a stimulated body fluid(SBF),hence they were applicable to be the bioactive scaffolds for bone tissue engineering.