SELECTED ENDOCRINE CASES THAT WILL KNOCK YOUR SOCKS OFF -PARTS IAND II

摘要

Pituitary-induced bilateral adrenocortical hyperplasia also known as pituitary-dependent Cushing's disease (PDH) accounts for about 85% of all cases of spontaneous hypercortisolism in the dog. It results from either an adenohypo-physeal ACTH-secretingmicro- or macroadenoma or from excess pituitary ACTH secretion due to oversecretion of corticotrophin releasing factor (CRF) by the hypothalamus. The end result of both processes is hypersecretion of ACTH causing bilateral adrenocortical hyperplasia and subsequent hypercortisolism. Adrenal tumors consist of either functional adenomas or adenocarcinomas of the adrenal cortex. These comprise 10-15% of all causes of spontaneous Cushing's syndrome in dogs.