Transcription of MMP-2 and MMP-9 in Horses With CHO-Induced Laminitis Treated With an Intracecal Buffering Solution

摘要

Degradation of the lamellar basement membrane by matrix metalloproteinase enzymes (MMP) repre-sents a critical early event in the pathogenesis of equine laminitis. Under normal physiological states, controlled dissolution allows the growth of the hoof; however, when excessive activation of these enzymes occurs, it leads to separation of the epidermal from the dermal laminae. This study compared the gene expressions of MMP-2 and MMP-9 during clinical development of carbohydrate (CHO)-induced laminitis when saline or buffer solu-tion was administrated intracecally.