We report on the implementation of a narrow-band image (NBI)-guided Raman endoscopy for in vivo diagnosis of gastric dysplasia. High-quality in vivo Raman spectra can be acquired from normal and dysplastic gastric tissue within 0.5 second at gastroscopy. Significant Raman spectral differences are observed between normal and dysplastic gastric tissue. PCA-LDA modeling on in vivo Raman spectra yields a diagnostic sensitivity of 94.4% and specificity of 96.3% for distinction of gastric dysplastic tissue. This study suggests that NBI-guided Raman endoscopy associated with PCA-LDA algorithms has potential for noninvasive, in vivo diagnosis and detection of gastric precancer during clinical gastroscopic examination.
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