Interaction Of EGCG Molecules With Silver- Lysozyme Complex By SERS Measurements

摘要

(-)-Epigallocatechin gallate (EGCG), a potent antioxidant, is reported to show anticancer activity and is presently under investigation in clinical studies. It is also shown to have several antibacterial activities. On the other hand, lysozyme (Lys), a small monomeric globular protein consisting of 129 amino acids, has the ability to disrupt many bacterial functions including their membrane structure. In view of their multifarious functions and important practical role from a medicinal point of view of both Lys and EGCG, interaction studies between Lys and EGCG are necessary in order to realize the disposition, transportation and metabolism of ligands.