EFFECTIVENESS OF TIAMULIN IN FEED FOR CONTROL AND TREATMENT OF PORCINE PROLIFERATIVE ENTEROPATHY (ILEITIS) DUE TO LAWSONIA INTRACELLULARIS INFECTION

摘要

Porcine Proliferative Enteropathy (PPE, ileitis) is a common enteric disease of grow-finish swine which may result in poor growth rate, diarrhea, and stunting or may be manifested as sudden death or bloody diarrhea in late finishing pigs and replacement gilts(l). The causative organism, Lawsonia intracellularis (LI)(2) is a fastidious and obligatery intracellular bacterium. The inoculation of pigs with pure cultures of LI has allowed successful reproduction of disease without the confounding effect of other potentially pathogenic microflora and variability of infective dose inherent in crude inoculum preparations(2). Tiamulin (Denagard~(TM)) is a member of the pleuromutilin family of antibiotics, which are selectively reserved for use in food producing animals and are not used in human medicine. Tiamulin achieves high tissue levels in both the enteric and respiratory tracts. Tiamulin has good in vitro activity against gram positive bacteria, mycoplasmas, anaerobes, spirochetes (e.g. Brachyspira/Serpulina spp.), and selective gram negative activity including Actinobacillus pleuropneumoniae, Haemophilus parasuis, Pasteurella multocida and Lawsonia intracellularis(3).