SIMULATING BRAIN INTERACTION OF SYNAPTIC POTENTIALS AND POSTSYNAPTIC INHIBITION

摘要

Information processing in the brain results from the spread and interaction of electrical and chemical signals within and among neurons. The equations that describe brain dynamics generally do not have analytical solutions. The recent expansion in the use of simulation tools in the field of neuroscience has been encouraged by the rapid growth of quantitative observations that both stimulate and constrain the formulation of new hypotheses of neuronal function. We use the NEURON simulation environment as it provides a powerful and flexible environment for implementing biologically realistic models of electrical and chemical signaling in neurons and networks of neurons. In this research we focus on synaptic potentials interaction as well as on the influence of excitatory and inhibitory neurotransmitters on the conductance changes. We concentrate our attention on influence of gamma (γ)-aminobutyric acid (GABA) as many mental disorders are thought to be due to disturbances in postsynaptic inhibition.