Harnessing Graft-Versus-Leukemia Without Myeloablative Therapy

摘要

High-dose chemotherapy and allogeneic progenitor cell transplantation has been used as a curative therapy for many patients with hema-tologic malignancies. However, because of the toxicity of myeloablative conditioning it had been limited to young patients in good medical condition. The use of less intensive nonablative regimens may provide a strategy that allows exploitation of the graft-versus-leukemia effect in older and debilitated patients.