TEMPLATED AND ACTIVATED CARBONS FOR THE ADSORPTION AND CONTROLLED RELEASE OF DRUGS

摘要

The development of a drug delivery system comprises different aspects,being the drug delivery materials one of the most relevant.A variety of drug carriers have been studied in literature,polymers,peptides,hydrogels,porous materials.MOFs,silica and carbons are among the porous materials most studied.Large pore volume and surface area,tuneable pore size,high stability in aqueous media and excellent biocompatibility made carbon porous materials as a suitable candidate in drug delivery system applications.Carbon-based nanocarriers such as carbon nanotubes,fullerenes and mesoporous carbons have been explore Ibuprofen(2-(4-isobutylphenyl)propionic acid)is one of the medicaments more used since it is a non-steroidal anti-inflammatory and analgesic drug.It is a well-characterized drug,commonly used as a release drug model.In this work,we propose porous carbons as a good candidates for drug release systems,due to the properties that make them adequate for this application:large pore volume,high surface area,tailored pore size,mouldable surface chemistry,high stability in aqueous media and excellent biocompatibility4.Thus,three different carbons:microporous carbon(SXPlus),carbon with ordered mesoporosity(C.SBA-15),and carbon submicrocapsules with a hollow nucleus and a mesoporous shell(CSC).