OPTIMIZATION OF THE WALL THICKNESS DISTRIBUTION OF PHARMACEUTICAL PRESS-THROUGH BLISTERS

摘要

Thin wall sections of medical press-through blisters may reduce the stability of the packed medicine. A homogeneous wall thickness over the entire capsule chamber enables the manufacturer to use a thinner starting foil without a lack of quality, which leads to the saving of raw material and other expenditures. Three thermoforming methods are tested on an industrial "form-fill-seal" line. The temperature profile of the raw film before forming, the friction coefficient between films and molds or plugs and the biaxial rheological properties of the foil influence the resulting wall thickness distribution.