Antimicrobial susceptibility patterns of salmonella isolates of veterinary origin

摘要

The emergence of resistance 10 antimicrobials has compromised control of many bacterial pathogens and has emerged as a global problem. The intestinal flora of animals that have been treated or prophylaxed with antimicrobial agents can serve as a reservoir of resistance factors. Because of the public health concerns associated with the approval of fluoroquinolones for use in food-producing animals, an antimicrobial resistance monitoring program was proposed by the Food and Drug Administration Centerfor Veterinary Medicine (FDA) as a post-marketing activity to help ensure the continued safely and effectiveness of the fluoroquinolones. In late 1995, CDC, the USDA, and the FDA established the National Antimicrobial Susceptibility Monitoring System toprospectively monitor changes in antimicrobial susceptibilities of zoonotic pathogens from human and animal clinical specimens, from healthy farm animals, and from carcasses of food-producing animals at slaughter. Non-typhoid Salmonella was selected asthe sentinel organism because it is an important food borne pathogen, it is ubiquitous in nature, it is reportable for CDC, and bodi human and veterinary isolates are available. Isolates are selected from testing conducted by the USDA or collaborators, from the National Animal Health Monitoring System studies, from clinical sources, especially from the National Veterinary Services Laboratories, and from slaughter samples. Testing is done using a semi-automated system (Sensititre~(TM) Accumed, Westlake'Ohio) for the testing of isolates. All isolates are maintained at -70 deg C to serve as a bank for future use.