Supercritical carbon dioxide (SC-CO_2), n-butane and mixture of n-propane:n-butane were used as reaction media for esterification of oleic acid with oleyl alcohol catalyzed by immobilized lipase from Rhizomucor miehei. Syntheses were performed in different reactors: bath stirred tank reactor and packed bed continuous operated reactor at atmospheric pressure and at high pressure. Influence of reaction parameters on initial reaction rates as well as on equilibrium conversion was studied. Results obtained in all types of reactor were compared.
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