Effect of liposomes-encapsulated dopamine on experimental parkinsonian syndrome in rats after striatum administration

摘要

Parkinsonian syndrome (PS) is considred to be the result of damage of nigral dopaminergic neurons leading to reduction of dopamine (DA) level in striatum. L-dihydroxiphenylalanine(L-DOPA), the precursors of dopamine which easily cross the the blood-brain barrier (BBB) is used as the most effective form of therapy for PS. However, chronic use of L-DOPA therapy often causes different side effects.