Release of Dehydroepi and roster one from nanopar ticles composed of poly(L-lactic acid) and poly(ethylene oxide) diblock copolymer endcapped with sugar moiety

摘要

Active targeting of drugs using receptor-mediated delivery has been proposed as a potential method for sitespeicfic delivery of drugs, proteins and genes to cell possessing carbohydrate receptors on the cell surface because of changing the body distribution of drugs and obviation of unwanted side effects. Among them, asialoglycoprotein receptor on the hepatocytes has been proposed as a useful means to target liver-specific chemotherapy using galactose moiety.