In Vitro Performance of Vacuum Plasma Sprayed Coatings on Carbon Fiber Reinforced Poly(etheretherketone)

摘要

In the present study, short-term in vitro stability of VPS-HA coatings on CF/PEEK was investigated. VPS-coating stability tests were performed in two simulated physiological solutions to study the in vitro dissolution behavior of the HA-coatings. Further, extraction tests were carried out to study whether certain products which were formed during the VPS process might leach out or dissolve during in vitro extraction and adversely affect cell-performance of MC3T3E1 osteoblastic cell-line. Stability testing of VPS-HA coated CF/PEEK substrates in two simulated physiological solutions, SBF and Ringer solution, at 37deg C for up to 28 days showed a complex transformation reaction, including dissolution of mainly TCP and precipitation of calcium phosphate occurred within the first day. Coating thickness determination showed that no significant reduction of coating thickness was observed within the experimental time scale. It is therefore concluded that coating thickness and integrity was not affected within 28 days of immersion. Further, it was shown that mitochondrial and lysosomal activity was not affected by the extract solutions at any concentration and treatment period tested. It is therefore concluded that no products which affect basic cell functions were extracted during the immersion time interval considered in this study.