Optical resolution of homopipecolic acid benzyl ester by high pressure crystallization

机译：通过高压结晶均己酸苄基酯的光学分辨率

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The aim of this study is to get the fundamental data for the optical resolution by high pressure crystallization. The separation of racemates into their optical isomers on homopipecolic acid benzyl ester (HABE0 by high pressure crystallization was investigated. HABE is the precursor of the drug for kidney disease. The solubility curves of HABE in ethanol as a function of R-siomer fraction was measured at given temperature (30 deg) and under various pressure (0.1 approx 300 MPa) at 30 deg. It was found that the solubility diagram showed two eutectic points, and that the interval of two eutectic points became narrow from 60 to 48

机译：本研究的目的是通过高压结晶获得光学分辨率的基本数据。研究了外消旋物在均己酸苄基酯（通过高压结晶Habe0的光学异构体的分离。哈维是肾病药物的前体。测量乙醇中酸壳的溶解度曲线作为R-Siomer级分的函数在30℃的给定温度（30℃）和各种压力下（0.1大约300MPa）。发现溶解度图显示了两个共晶点，并且两个共晶点的间隔从60到48变窄

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《International symposium on industrial crystallization of China》|1998年||共5页
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H.Yamamoto; Y.Takemura; K.Ogawa; Y.Takemura; T.Ueda; Y.Harano; K.Kagara; M.Moritoki;
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中图分类晶体化学;
关键词
high pressure crystallization; optical resolution; enantiomer; racemate; homopipecolic acid benzyl ester;

机译：高压结晶;光学分辨率;对映体;外消旋体;均己酸苄酯;
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机译：（RS）-2-苯甲酰氨基-2-苄基-3-羟基丙酸的优先结晶光学拆分及其在合成光学活性2-氨基-2-甲基-3-苯基丙酸中的应用。
2. Crystallization-based resolution process for the 2,3-dibenzoyl-D/L-tartrate salts of D-/L-serine benzyl ester [J] . Sistla V.S., Lorenz H., Seidel-Morgenstern A. Crystal growth & design . 2013,第6期

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4. Optical resolution of homopipecolic acid benzyl ester by high pressure crystallization [C] . H.Yamamoto, Y.Takemura, K.Ogawa, International symposium on industrial crystallization of China . 1998

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6. Preparation of Novel meta- and para-Substituted N-Benzyl Protected Quinuclidine Esters and Their Resolution with Butyrylcholinesterase [O] . Ines Primožič, Marijana Bolant, Alma Ramić, 2012

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机译：通过（RS）-2-苯甲酰基亚氨基-2-苄基-3-羟丙基甲酸的优先结晶和用于合成光学活性的2-氨基-2-甲基-3-苯基丙酸的光学分辨率的光学分辨率。

Optical resolution of homopipecolic acid benzyl ester by high pressure crystallization

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