Differential thermal wave radiometry for noninvasive blood glucose monitoring: feasibility analysis

摘要

Blood glucose monitoring is essential for management of diabetes especially for those patients who require regular insulin injections. A reliable noninvasive technique may eliminate inconvenience associated with frequent skin puncture to draw blood for measurement by a standard meter. Laser-induced thermal waves in tissue and detection of resulting IR response may provide a valuable approach to development of a noninvasive glucose sensor. The present report analyzes radiometric response of tissue at the two wavelengths in mid-IR spectral band with phase-sensitive detection to evaluate feasibility of differential phase radiometry for noninvasive glucose monitoring. Sensitivity of the differential phase method is computed using two models of laser-tissue interaction: homogeneous light absorption and a discrete chromophore heating.