Preliminary fluorescence study in vivo on the distribution of trisulfonated aluminum phthalocyanine in tumor-bearing mice

摘要

Phthalocyanines (PC), e.g., trisulfonated aluminum phthalocyanine (AlS$-3$/PC), had recently been considered as an efficacious photosensitizer used in photodynamic therapy (PDT) of tumor. Moreover, it might have potential usage in tumor detection due to its high fluorescence quantum yields (0.52, much higher than that of HPD). It is significant to study the fluorescence distribution of AlS$-3$/PC for tumor PDT and tumor detection. In vivo fluorescence measurement on mice bearing S$-180$/ fibrosarcoma, through the using of He-Ne laser excitement, showed that AlS$-3$/PC ($GREQ 96%, synthesized and purified by our group) can selectively retain in S$-180$/ fibrosarcoma and the maximum ratio of the relative fluorescence in tumor area to that in nomal area 24 - 48 h after AlS$-3$/PC injection (i.p.) is about 2.9/1.