Optimal experiment design for identification compartmental modelparameters of therapeutic processes

摘要

The knowledge of model parameters allows assessment of the actualstate of a system using compartmental identification procedure. Forsatisfactory solution of the problem the optimal experiment design isnecessary to adopt. Three co-operating computer programs are designed:MFIT, OSSP and OIN. MFIT enables to choose the best from any reasonablemodel functions. Reduced sampling schedule (OSSP) and optimal input(OIN) are obtained on the basis of output files of MFIT. The finaloptimal experiment design is obtained by repeating the procedure. Thedesign is optimal by a way of compromise between essential estimatesaccuracy, reduced number of samples and the closest to optimal if notstrict optimal, input