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Production of Functional Microtool Using Size-Classified Gel-Microbeads

机译:使用尺寸分类的凝胶微珠生产功能性微型工具

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In this study, we succeeded in producing functional microtool made of gel-microbead using size-dependent microparticle classification. Gel-microbead, which is used as the material for the microtool, is made by salting-out of hydrophilic photo-crosslinkable resin, ENT-3400. These gel-microbeads were separated according to their size by microfilters made of polydimethylsiloxane (PDMS). A first on is a row of fluidic micro-channels which block microbeads with a size over the width of the channel. Another filtering method has been experimented, using Magnetically driven MicroTool (MMT) to separate the beads using the centrifugal force created by this MMT actuated with a DC motor. Separated gel-microbeads were recovered after filtering step and then used to fabricate functional microtools, for example tether-shaped gel-tool, by contact to other gel-microbeads under UV illumination. Produced gel-tool is manipulated by optical tweezers in a microchip. We succeeded in getting size-dependent separation of the gel-microbeads and production of the tether-shaped gel-tool.
机译:在这项研究中,我们成功地使用尺寸依赖的微粒分类技术生产了由凝胶微珠制成的功能性微型工具。凝胶微珠是用作微型工具的材料,它是通过将亲水性光可交联树脂ENT-3400盐析而制成的。这些凝胶微珠通过由聚二甲基硅氧烷(PDMS)制成的微滤器根据其大小进行分离。首先是一排流体微通道,该微通道阻塞在通道宽度上具有一定尺寸的微珠。已经尝试了另一种过滤方法,使用磁力驱动的MicroTool(MMT)来分离珠子,该离心力是由由DC马达驱动的MMT产生的离心力产生的。在过滤步骤之后,回收分离的凝胶微珠,然后通过在紫外线照射下与其他凝胶微珠接触,将其用于制造功能性微工具,例如系绳状凝胶工具。生产的凝胶工具由微芯片中的光学镊子操纵。我们成功地实现了凝胶微珠的尺寸依赖性分离和系绳状凝胶工具的生产。

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