Implant-assisted magnetic targeting of gold drug carriers in capillary beds

摘要

The feasibility of targeting nanosizegold drug carriersby using a ferromagnetic wire implanted in capillary beds is studied theoretically. An external uniform magnetic field is applied transversely to the wire to produce high gradient magnetic field which produce magnetic force acting on the carriers in the vicinity of wire surface. The study of gold drug carriers' motion in capillary beds under the influences of magnetic force and blood flow is simplified by neglecting the effect of capillaries' walls. Equations of motion of the carriers are formulated and are solved numerically to obtain carriers' trajectories. By analyzing carriers' trajectories, the feasibility of capturing gold drug carriers near wire surface can be examined and the capture efficacy can be estimated for various parameters suchas the strength of applied uniform magnetic field, the radius of gold drug carrier and the radius of the wire. The results show the feasibility of targeting gold drug carriers in capillary beds by using the implant. Information from this study are useful for developing techniques for magnetic targeting of gold drug which are now used for cancer and tumor therapies.