Continuous Dynamic Bayesian Network for gene regulatory network modelling

摘要

In order to understand the underlying function of organisms, it is necessary to study the behaviour of genes in a gene regulatory network context. Several computational approaches are available for modelling gene regulatory networks with different datasets. Hence, this research is conducted to model the gene regulatory gene network using the proposed computational approach which is the Dynamic Bayesian Network. Dynamic Bayesian Network (DBN) is extensively used to construct GRNs based on its ability to handle microarray data and modelling feedback loops (cyclic regulation). The DBN approach is then extended to the continuous Dynamic Bayesian Network (cDBN) to construct a gene regulatory network with continuous data without discretization. The performance of the constructed gene networks of Saccharomyces cerevisiae were evaluated and compared with the previous works. At the end of this research, the gene networks constructed for Saccharomy cescerevisiae discovered more potential interactions between genes. Therefore, it can be concluded that the performance of the gene regulatory networks constructed using continuous dynamic Bayesian networks in this research is proven to be better because it can reveal more gene relationships as well as allowing feedback loops or cyclic regulation.