Curcumin-nanodiamond-silk wound dressings for sensing infection

摘要

The presence of an infection in a wound site is typically diagnosed based on the external appearance, such asredness, swelling, odour, and/or loss of function. However, this can lead to inaccurate and untimely diagnoses,since an infection might be present without obvious symptoms. This would commonly require removal of anydressing that might be present, which can cause further pain to the patient. Therefore, there is a need for moreprecise methods of detecting infections, with minimal effects to the patient. Comparison of temperaturedifferences between infected tissue and healthy tissue shows an increase ranging from 3-4°C, while normal skinhas a temperature gradient of ±1°C. Hence, monitoring temperature of wounds can be used to detect thepresence of an infection.Nanodiamonds (NDs) containing negatively charged nitrogen-vacancy (NV~-) centres are capable of monitoringchanges in temperature with minimal influence by environmental factors such as pH, ion concentration ormolecular interaction. This study looks at encapsulating these NDs into silk fibres for use as a wound dressingthat can monitor temperature changes in the wound, without requiring the removal of the dressing. To furtherenhance the wound healing and anti-bacterial properties, curcumin was also incorporated into the silk fibres.Curcumin is one of the active ingredients in turmeric and is known to significantly enhance wound healingthrough its anti-inflammatory and antibacterial properties. This study used this curcumin-nanodiamond-silkhybrid wound dressing to investigate the healing capabilities and temperature sensing properties for use as awound dressing.