Background/Aim: Some phenols are endocrine disruptors commonly used in production of personal care products (PCP). These compounds have a short half-life and past studies have reported detection of some parabens in urine as early as 3 hours after use of PCP. This study aimed at assessing temporal effects of PCP use on urinary concentrations of phenols in an intra-individual study considering shorter and multiple time windows of exposure. Methods: We assayed concentrations of 10 phenols in 114 urine samples from 2 pregnant women collected over a week. Participants also filled detailed diaries with exact time of use of 16 PCP and time for urine collection. We characterized use of PCP as, a) use of a specific PCP (yeso) b) sum of PCP used in each time window, categorized in 3 percentiles. We used linear mixed models to examine the association between the sum and single PCP use in 6,12 or 24 hours prior to urine collection and urinary phenol concentrations. Results: Sum of PCP use was associated with increased urinary concentrations of the parabens. The implicated parabens varied by time-window of exposure, in 6 hours, ethly and butyl paraben, in 12 hours, propyl paraben and in 24 hours, methyl and propyl paraben. Single use of coloured cosmetics, deodorant, shampoo, conditioner and face cream was also associated with increased urinary concentrations of parabens across the 3 time windows. We did not observe clear associations with the other phenols; bisphenol A and S, 2,4 and 2,5 dichlorophenols, benzophenone-3 and triclosan. Conclusion: These results elaborate further that PCP are important sources of exposure to parabens in pregnant women and that effects of PCP use on the 4 paraben urinary concentrations varied by time window of exposure.
展开▼
