The main inert gas isotopes application areas, the required purity and preparation methods were reviewed.Cryogenic rectification, gas centrifugation and gas thermal diffusion are traditional methods for isotopeseparation. Their work principles were analyzed, the main shortcomings were indicated, the separation factorand application area were determined. The low-temperature physical adsorption, which eliminates thedisadvantages of the above methods, was proposed. The main requirements for a research facility for lowtemperatureinert gas isotopes adsorption were formulated. The experimental unit design was proposed. Thetests will enable to determine the inert gas isotope mixtures separation efficiency and the each isotopedesorption time, to build adsorption isotherms for isotopes on different adsorbents, to calculate adsorptionenergy and the separation factor. The data obtained will be used to estimate the efficiency of the lowtemperatureadsorption separation with considering thermal diffusion, centrifugation and rectification. Theresults will allow to estimate the mass and dimensional characteristics of the adsorption unit and its total energyconsumption.
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