A process of health-saving accompaniment individualization implies constant monitoring of the functional state. There isa universal method of instrumental evaluation and prediction of the human adaptive state, considering its individual,genetically determined structural and functional characteristics. It is a method of LGNRO assessment. LGNRO is for alevel of general nonspecific reactivity of an organism, qualitatively and quantitatively characterizing a level of individualsensitivity and reactivity to various exogenous effects. The biometric analysis of the organism’s nociceptivecharacteristics has revealed the general biological character of the normal distribution of the thermal sensitivity threshold(TST) in human populations and laboratory animals. The possibility of a rapid assessment of LGNRO by means of TSTis justified. Morphofunctional characteristics of individual brain structures and their role in the formation of LGNROhave been determined. The genetic determinancy of phenotypic manifestations of LGNRO has been proved. Based onthe results of experimental studies, an algorithm and a corresponding computer program have been developed thatprovides system-specific personalized monitoring of human health status in real time.
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