Objective: To observe the efficiency and safety of hematoporphyrin mono-methylether photodynamic therapy(HMME-PDT) in treating port-wine stains (PWS) with Chinese patients, and to evaluate the advantage of photograph、VISIA-CRTM system, and dermoscopy in efficacy evaluation. Method:52 patients were treated in our hospital over thepast two years with HMME-PDT ,among which, 15 cases were pink type, 29 cases were purple type and remain 8 caseswere Nodular thickening type. Initially, All patients received an intravenous injection of 5 mg/kg HMME ,and then thelesion areas of the patients were exposed to 532 nm LED green light after 10 minutes. The irradiation power density wasrange between 80–95 mW/cm~2. By utilization of photograph、VISIA-CRTM system, and dermoscopy to evaluate theclearance after treatments, and then informing the patients to rank the pain level during the treatment via VAS scale, andrecording the side effects.Result:After 1-7 times treatments.13 of the 52 cases were cured (25.00%) , 14 cases showed agood efficacy (26.92%), 16 cases indicates alleviation (30.77%), while 9 cases displayed no efficacy (17.31%).Byobservation, it showed that the pain level each patient could endure were distinct, and it’s remarkable that whenreceiving consecutive 11-12min of treatment, most of patients have showed with severe pain (according to VAS scale).The side effects after treatment mainly displayed with edema，crust，hyperpigmentation.Conclusion: it shows that aftertreating with HMME-PDT ,the efficacy is remarkable and with advantage of safety and less side effects, whichworthwhile for further research and promotion.
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