Periodic bulk motion correction method in decorrelation-based　optical coherence tomography angiography

摘要

Decorrelation-based OCTA is a widely used optical coherence tomography angiography method which utilizes OCTintensity information. However, cardiac and respiratory motions in animals are seriously degrade image quality. Thesekind of bulk motion is periodic, and its C-Scan (slow scan) direction component hinder motion correction because of scanposition and OCT structure’s change. Some correction methods were proposed, but vasculature information will be lostwhen larger bulk motion occur. Here we demonstrate a correction method which uses stitch scan protocol in C-Scandirection, and sets a threshold to the maximum value of normalized cross-correlation among repeated B-Scan intensitysignal to exclude false OCT B-scans. Result of In vivo imaging experiment for mice indicates that our method can reservewhole vasculature information and effectively improve image quality.