Design and Analysis of Silicon Carbide Microneedle for Transdermal Drug Delivery

摘要

In this paper, we present an out-of-plane microneedle for transdermal drug delivery application. The proposed design is strong enough to reduce stresses and deformation having a length of 380 µm, outer diameter of 70 µm, and inner diameter of 40 µm. The dimension of the proposed microstructured needle can be a model for painless drug delivery. A side port design of microneedle is conducted for an efficient drug delivery. The analysis and simulation of the design has been carried out using COMSOL Multiphysics where different materials are used. Silicon Carbide (SiC) based microneedle has been performed as a less deformation microneedle compared to the other selected materials. Moreover, the simulation result represents a significant change in stress with the variation of the needle tip area. The bending and the compressive force analysis are also examined which determines that the microneedle can withstand without breaking if the generated stress at the needle body is under the yield strength of the material.