Mars is the next frontier for the space explorers to demonstrate the extent of human presence in space beyond low-earth orbit. Both government and private space industries have been fascinated by Mars quest to attempt a crewed expedition to the red planet. The journey to Mars is vastly challenging as it endowed with numerous challenges from the inception of the mission engage to the mission achievement. Therefore, it is substantial to overcome those challenges for a reliable mission. Hence we have studied and emphasized the comprehensive challenges under the categorization of terrestrial, Earth-bound, interplanetary, Mars-bound, and planetary surface challenges. These challenges are suspected to encounter by the astronauts and mission planners throughout the mission timeline. Our research is different from other studies as it reports complete challenges and their implications on the way to human exploration of Mars.
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