Magnetic Nanoparticles Localization in Ophthalmologic Surgery

摘要

This study explores the nature of the localization of magnetic nanoparticles using various magnetic designs and circuitry. With theoretical analysis, software simulations, and experimental trials, devices that have sufficient power and accuracy to propel nanoscale particles through various ocular media are optimized. Electromagnet designs prove to be ineffective due to the lack of power at the scale desired for surgical implementation. Magnetic circuits also lacked the needed magnetic strength due to complications of the magnetic coupling materials. Neodymium permanent magnet devices proved to be the most effective method of controlling the motion of magnetic nanoparticles while maintaining dimensions that would allow surgeons manual control.